Cart
sales@molnova.com
TC-N 1752
CAS No. 1211866-85-1
TC-N 1752 ( —— )
Catalog No. M27722 CAS No. 1211866-85-1
human NaV1.7 channels blocker.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 110 | Get Quote |
|
| 10MG | 178 | Get Quote |
|
| 25MG | 410 | Get Quote |
|
| 50MG | 605 | Get Quote |
|
| 100MG | 860 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameTC-N 1752
-
NoteResearch use only, not for human use.
-
Brief Descriptionhuman NaV1.7 channels blocker.
-
Descriptionhuman NaV1.7 channels blocker.(In Vitro):TC-N 1752 exhibits IC50s of 0.2, 0.1, 1.6, 0.5 and 1.4 μM for hNav1.7, hNav1.8, hNav1.9, rNav1.9, and mNav1.9. TC-N 1752 state-dependently inhibits Nav1.7 channel on channels that are 20% inactivated(IC50 = 170 nM) and on fully noninactivated channels(IC50 = 3.6 μM).(In Vivo):TC-N 1752 (5 mg/ml; i.v.) attenuates Freund's adjuvant-induced sensitization of C fiber nociceptors. TC-N 1752 (3-30 mg/kg; orally) exhibits analgesic effects in a dose-dependent manner in a formalin model and reduces thermal hyperalgesia produced by inflammation.
-
Synonyms——
-
PathwayOthers
-
TargetOther Targets
-
Recptor——
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1211866-85-1
-
Formula Weight516.5
-
Molecular FormulaC25H27F3N6O3
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESC\C(O)=N\c1cccc(\N=c2/ncnc([nH]2)N2CCC(CC2)OCc2ccc(OC(F)(F)F)cc2)c1C
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Wang RY, et al. From kinetic-structure analysis to engineering crystalline fiber networks in soft materials. Phys Chem Chem Phys. 2013 Mar 7;15(9):3313-9.
molnova catalog
related products
-
Quinfamide
Quinfamide is a compound with the potential to treat tropical parasitic infections such as Amoebiasis and Helminthiasis.
-
Methyl octanoate
Methyl octanoate is a volatile compound and an aroma component persimmon wine.
-
Co 102862
Co 102862 is a voltage-gated sodium channel blocker. Co 102862 can be used for anticonvulsant studies.
